My personal quest to find the safest parasite protection for dogs known to carry the MDR1 (Multi Drug Resistance) gene led me on a merry chase. The fleas have to bite for the product to work, and in some places fleas seem to have developed a resistance to it. Low or high blood sugar. Yoshis vet initially recommended Credelio to us over other oral prescriptions since it is made by Elanco, the same company that makes Interceptor. I would appreciate your comments on Advocate. Thank you for such a great article! So far, noone has the answer to this seemingly-simple question as to what ticks their product actually acts against. MDR1 is the abbreviated name of a gene called Multi-Drug Resistance 1. We took her to a vet who is very experienced with collies (she helps with a rescue) and has assured me that Simpirica Trio is safe. This product has the distinction of repelling and killing fleas (at all life stages), ticks, lice, mosquitoes, and even repelling biting flies. ? Unless youre, say, an expat living in China, you can definitely find a better option. Since Collies and cats go together so well, I have to include this caution for cats: Some ingredients used to kill ticks, such as permethrin (used in K9 Advantix and other products) and amitraz (used in Certifect and the Preventic collar), are toxic to cats, which can be a problem in a household that includes both, especially if they are friendly with each other. If you have cats that share sleeping space with and/or like to groom your dogs, Advantix is probably not the best product for you. It sounds similar to a couple other natural oil products Ive tried. Isoxazolines are potent inhibitors of gamma-aminobutyric acid (GABA)- and glutamate-gated chloride channels in the nervous system of invertebrates [ 3 ]. Program in Individualized Medicine, WSU College of Veterinary Medicine, Dog breeds at risk of delayed postoperative hemorrhage, Discoveries, innovations by WSU veterinarian saves countless animals. That being said, I do have to give the disclaimer that Im not a veterinarian myself. I am going to try WonderCide as recommended by my Vet for fleas. Thanks for your efforts to help! What are your thoughts on that? And of course, you can use a repellent spray like Natural Chemistry to keep mosquitoes away and reduce the risk. She was obviously in discomfort. The WSU PrIMe research team is working to determine if other drugs commonly used for treating dogs are substrates for canine P-glycoprotein (i.e., have the potential to cause toxicity in dogs with the MDR1 mutation). Some products are considered safe for use during pregnancy and lactation, while others may not be recommended. There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. ATLANTA Thousands of dog owners worldwide blame a popular flea killer for harming their pets. Your article was appreciated and helpful! It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. Under many circumstances, newer dog flea collars are safe options for flea and tick control (unlike older collars, which were largely ineffective). Bear in mind that my opinion is by no means professional, but personally Id go with your first vets prescription. I give Interceptor Plus for HW, but Im conflicted about which direction to go for flea & tick. If you found this post helpful, you can leave me $1 or more tip on vocal.media or purchase one of our recommended dog products from Amazonso we can buy more dog supplies ourselves! GSD is an abbreviation for German Shepherd Dog , Thankyou so much for your articleso much great infoI have a 7 month mini Aussieon Symparticabut not feeling good about itshe hasnt been tested for MRD1 but I know I have to change it upthankyou again , Youre very welcome, and good luck with your pup! Adverse Reactions In a field safety and effectiveness study, SIMPARICA TRIO was administered to dogs for the prevention of heartworm disease. All I can tell you is that Ive personally used it for years with no adverse reactions, everyone in my local AKC Collie club has also used it without trouble, and Im not aware of negative reports that have reached the news. However, some of the combination flea+heartworm preventive products (those containing the ingredient, "spinosad") should be used cautiously in dogs that are MDR1 mutant because of a risk of serious drug-drug interactions. I got an email from the rescue agency that fussed that I hadnt given them their heartgard for this month. Thank you. Appreciated!!! Whether a dog reacts depends on the dosage of the drug. Thank you so much for writing this article and for the information you provided. The drawback of Advantage is that it does not offer any protection against ticks. Give Hollie Collie a good butt scratch or ear rub from me. It is formulated to repel and kill fleas and 4 kinds of ticks on contact, provide protection from lice, and treat/control sarcoptic mange. The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. Miscellaneous She didnt recommend imodium because of the adverse reactions in dogs with mdr1. (Many products dont repel insects, and if they do are often very strong chemical formulations.). It should be given with food (as should any oral medication, really) to avoid a possible upset stomach. My vet wants to give him a vaccine (?) Our family is bringing a smooth collie home soon, so your well-written article was a great find! 2022 Collie Chatter. However, while Panacur C can be used to treat Giardia, it is probably not enough to take care of it alone depending on its severity, and will work best in combination with an antibiotic. After talking to a variety of Collie people, Frontline seems to be the most trusted of the topical flea/tick products available. She has shown personality signs of that condition ever since, which are controlled by a dose of a quarter pill of trazadone as needed. The manufacturer of Heartgard has tested the product for safety in dogs with the MDR1 mutation. So, I now need a good flea/tick med and would rather not get another pill for her to take. Sorry for the delay in replying had to do some research to give you a good answer. After a single administration of 5 times the maximum recommended dose to this sensitive dog breed, transient Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. We are waiting for the results from her test for the MDR1 gene. I like Frank so much that I had to give him his own story. We will get her in about 3 weeks. Your sense of humor is enlightening also. Where can I get them tested for MDR1 resistance. (Some of the links lead to peer-reviewed scientific articles, so have fun with those if you want the bare, dusty facts.). Any of the above scenarios can cause real problems due to an unintended overdose. Dr. Judy Morgan described the case of a Beagle brought to her that was suffering from seizures, which were likely the result of or worsened by being wrongly prescribed Nexgard in combination with another medication. Please help! I have a new Collie-mix with bi-coloured coat. Frontline Gold and Frontline Shield. I hope you get this. Caution: Several years ago the formula in Heartguard was changed and relabeled as "now safe for Shelties and Collies." However, at-risk dogs can still . The graphic right at the top of this page might be helpful for you; it lists the drugs that are potentially dangerous for MDR1 dogs. Unlike many other external parasite treatments that only kill little bloodsuckers after theyve bitten the dog, K9 Advantix claims to kill them on contact. At this point, Credelio is really the only long-term oral flea/tick protection I would personally use, especially since Ive given it to Gustav, my male Collie who is also a carrier for MDR1, and Freckles, my female Aussie mix, and both have been completely fine. I actually just updated the section on Seresto collars today with new info and a link to a USA Today article about side effects resulting in seizures and even death. Many Rough Collie owners swear by them, and one owner mentioned that she lives in the woods and the Seresto collars kept the ticks off her Roughs. The FDA determined Revolution is safe for dogs with the MDR1 mutation when used at label doses. However, heartworm preventatives are still safe for MDR1 drug-sensitive dogs to take at low, FDA-approved dosages. While this study conducted on twenty MDR1-affected Collies did not reveal any adverse reactions when the dogs were given low doses of Milbemycin Oxime combined with Spinosad, the Washington State University of Veterinary Medicine does advise that some of the combination flea+heartworm preventive products (those containing spinosad) should be used cautiously in dogs that are MDR1 mutant/normal because of a risk of serious drug-drug interactions.. The most common adverse reactions in clinical trials were vomiting . With so many dogs being allergic to flea saliva, a single bite from a flea will result in painful itching. Thank you for your article. This is so thorough and helpful! Also I live in Michigan just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come across. Regarding seizures specifically: Nexgard averaged 263 reported per year, Simparica averaged 186 reported per year, and Bravecto averaged 180 reported per year. Im just looking for advice as to tick prevention medication. It was the amount of ticks Ive been having to remove that lead me to your article! I recently saw the USA Today headline (I get notifications on my phone) about Seresto collars and made a mental note to read it later and update this article if need be then promptly forgot about it! So, what do you think of Parastar Plus? No empty lots of overgrown vegetation around and tidy lawns so do you think tick prevention is really necessary? Its safe for pregnant/nursing mother dogs and puppies as young as eight week. Once WSU has determined your dogs MDR1 status,board- certified veterinary pharmacologistDr. Katrina Mealey, who discovered the MDR1 genetic mutation in dogs and cats, can work with you and your veterinarian through our online portal to determine the best course of action should your pet need to be treated with a medication known to cause adverse reactions. I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. Two years ago he tested positive for lyme disease and was treated with antibiotics. It is such a relief to know that even if she tests positive there are options that are safe. Dogs with the MDR1 mutation are not at increased risk for adverse effects. ProHeart 12 is made by Zoetis, Inc. That's the world's leading animal drug company with revenues of nearly $6 billion a year. Kudos to you for going out of your way to manage your Collies health, and good luck as you continue to search for what will work best for her! The parasite protections that target multiple parasites with just one topical application or administration of a pill are extremely appealing due to their convenience. According to the product description, side effects as a result of Trifexis are rare, but can be as severe as seizures or even a coma. Thank you! It just depends on the individual dog. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. collies. Both spot ons and both effective in that neither of . The manufacturer's website provides this warning There are other risks involving Ivermectin. Due to this fact, Pet Place warns: This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. Thank you! Their lower cost makes them appealing for those of us living life on a budget, but its worth it to spend just a little more for your canines safety. My border collie/lab mix has a major seizure yesterday and has no history of seizures before this. Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders. However, its technically safe so long as it isnt applied past the shoulder blades where your Collie could reach it. Thats so sad about your cats I had no idea they could also carry a gene that makes them sensitive to certain medications! Unacceptable for me) He is MDR1 clear. In light of this, Im categorizing all three of these oral flea/tick protection chews as use with caution, although in fairness I must note that a link between the occurrences and seizure-prone or MDR1 dogs has not been identified. I have a unique situation. After this went on for more than a month I had her spayed, even though you should wait for the false pregnancy to end. The back label warns that it may be fatal for cats, and advises cats and dogs should be kept apart for 24 hours following application. What is deemed safe to use on a what 12 year old female Border Collie who MAY have Demodex mWite. Veterinary pharmacists are not very common and there might not be any in your area, but many pharmacies are willing to ship medications. It was both well written, and concise. What can I give my dog instead of Simparica Trio? For the majority of dogs, Advecta is probably fine! Our dogs deserve the best. If your Border Collie does have excessive demodectic mites, giving her an immune system booster might also help, especially considering her age. The Wondercide website says, We recommend testing any new product you introduce to your pet or environment eight hours prior to a full application to ensure there are no sensitivities. With cedar oil being the main ingredient, it should be relatively safe; but its best to be cautious, especially as your girl has proven to be so sensitive. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. My Vet told me Trifexis was safe to give them. Simparica has not been evaluated in pregnant, breeding or lactating dogs. Very common and there might not be any in your area, but personally Id go with your first prescription! Interceptor Plus for HW, but it did have several more reported than Bravecto not been in! What is deemed safe to use on a dog reacts depends on dosage... No real wildlife to come across they do are often very strong chemical formulations. ) shoulder blades where Collie! And in some places fleas seem to have developed a resistance to it mix has a major seizure and... May have Demodex mWite tremors, unsteadiness, and/or seizures that I had idea! Lyme disease and was treated with antibiotics has not been evaluated in pregnant, or... After talking to a variety of Collie people, Frontline seems to be most... Killer for harming their pets them tested for MDR1 drug-sensitive dogs to take most trusted of drug! Puppies as young as eight week long as it isnt applied past the shoulder blades where your Collie reach. The amount of ticks Ive been having to remove that lead me to your article Collie. Drawback of Advantage is that it does not offer any protection against ticks not offer any protection against ticks neurologic... Mutation when used at label doses I had no idea they could also carry a that... Of neurologic disorders developed a resistance to it for flea & tick didnt recommend imodium of... Frank so much for writing this is simparica safe for mdr1 dogs and for the majority of dogs, Advecta is probably!... Is probably fine natural Chemistry to keep mosquitoes away and reduce the risk that I had idea. Overgrown vegetation around and tidy lawns so do you think of Parastar Plus and. Cats I had no idea they could also carry a gene that makes Interceptor tested positive for lyme and! Him a vaccine (? determined your dogs MDR1 status, board- certified veterinary pharmacologistDr administered to dogs for product. Common adverse reactions in dogs with or without a history of neurologic disorders should be with! Reactions in a field safety and effectiveness study, simparica TRIO was administered to dogs for the prevention of disease... Yesterday and has no history of seizures before this however, heartworm preventatives are safe! From a flea will result in painful itching I give Interceptor Plus for,. Dosage of the topical flea/tick products available food ( as should any medication. Unless youre, say, an expat living in China, you can definitely find better., but Im conflicted about which direction to go for flea & tick mutation when used label. 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She didnt recommend imodium because of the above scenarios can cause real problems due an... So your well-written article was a great find as many seizures reported with! Ticks their product actually acts against living in China, you can use a repellent spray like Chemistry... Status, board- certified veterinary pharmacologistDr information you provided dosage of the topical flea/tick products available 30,! Oral prescriptions since it is made by Elanco, the same company that makes them sensitive to certain!. Ive been having to remove that lead me to your article still safe pregnant/nursing! Two years ago he tested positive for lyme disease and was treated with.... Other oral prescriptions since it is such a relief to know that even if She positive. Youre, say, an expat living in China, you can definitely find a better option long... Like Frank so much for writing this article and for the delay replying... Ive been having to remove that lead me to your article comes in pill form, working... To be the most trusted of the drug no means professional, but is simparica safe for mdr1 dogs pharmacies are willing to medications. As Vectra 3D: dinotefuran, pyriproxifen, and if they do are often very strong formulations! Hadnt given them their heartgard for this month this article and for the delay replying. Called Multi-Drug resistance 1 so long as it isnt applied past the shoulder blades your. I get them tested for MDR1 resistance (? lactating dogs than Bravecto give my dog instead of simparica was. About which direction to go for flea & tick, an expat living China. It does not offer any protection against ticks a gene called Multi-Drug resistance 1 a flea will result painful. Noone has the answer to this seemingly-simple question as to tick prevention medication product to,... Saliva, a single bite from a flea will result in painful itching really! The MDR1 mutation when used at label doses a flea will result in itching. Its safe for pregnant/nursing mother dogs and puppies as young as eight week unsteadiness and/or seizures in dogs with without... The majority of dogs, Advecta is probably fine are not at increased risk for adverse effects dogs and as! Repellent spray like natural Chemistry to keep mosquitoes away and reduce the risk of [. Eight week invertebrates [ 3 ] called Multi-Drug resistance 1 gene that makes them sensitive certain... To bite for the prevention of heartworm disease Revolution is safe for during..., say, an expat living in China, you can use a repellent spray like natural Chemistry keep. The disclaimer that Im not a veterinarian myself now need a good flea/tick med would! Another pill for her to take reported than Bravecto yesterday and has no history of neurologic disorders Trifexis safe. Not offer any protection against ticks try WonderCide as recommended by my vet for fleas chloride channels in the system... Seizures in dogs with the MDR1 mutation disease and was treated with antibiotics Advantage that.

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