Its a horrible condition . If colon cancer is advanced or metastatic (spread to other areas of the body), capecitabine . If you need to talk, we'll listen. Bowel cancer means cancer that starts in the colon (large bowel) or back passage (rectum). You will see a doctor or nurse before you have chemotherapy. I had it in the winter and it was not fun. Call freephone 9 to 5 Monday to Friday or email us. We enrolled 663 patients (331 in nCT arm; 332 in nCRT arm) meeting inclusion criteria. I guess that makes me T3 N1b M0. I will start adjuvant (mop-up) chemotherapy on April 24, with oral Capecitabine (Xeloda) and IV oxilaplatin. Other rare skin changes include ulcers, raised areas of skin that may be itchy, being sensitive to sunlight and previously treated areas of skin with radiation can become irritated and inflamed. Chewing gum can help to keep the mouth moist. I hope my experience will give you hope and peace of mind. You may need a drip to give you extra platelets. AF (atrial fibrillation) in 2013 which I believe was caused by the chemo. Sometimes even with a scarf over mouth in air condition. This can cause symptoms including: Tell your doctor or nurse straight away if you notice any of these symptoms. You may get pain or discomfort in your tummy (abdomen). Toxic effects of capecitabine and fluorouracil were similar. It can affect your throat causing it to feel as though it is difficult to breathe and swallow. But some can be permanent. Encorafenib and Cetuximab Metastatic Colorectal Cancer Protocol V1.1. Getting to the park and walkling around got some exercise happening and just put me in a great mental state. So I had ginger snaps guilt free. Hi Topcatrs2000 and welcome back although Im sorry to hear that youre struggling. For example, if you need treatment for anything else, including teeth problems. You may gain weight while having this treatment. Contact with others who have had immunisations-You can be in contact with other people who have had live vaccines as injections. You should take them within 30 minutes of finishing a meal. you have diarrhoea more than 4 times in a day, you have a moderate or severe increase in stoma activity. Isle of Man company number 4694F. Your nurse can talk to you about ways to cope with hair loss. Roland KKeel People with weak immune systems can have these, as they are not live vaccinations. These side effects happen in between 1 and 10 out of every 100 people (between 1 and 10%). Randomisation was done . throbbing pain, redness or swelling in a leg or arm. Oxaliplatin and capecitabine is a chemotherapy combination known as XELOX. This treatment can cause changes to the lungs. The cold sensitivity is pretty bad for me. Very rarely, this can cause heart failure or a heart attack. This is serious and could be life threatening, a blood disorder where your red blood cells get destroyed faster than they can be made (haemolytic anaemia), high levels of a type of fat in your blood, panic attacks this can make you feel as though your heart is pounding, sweating, feeling weak and dizzy and having trouble breathing, problems with your balance and coordination of your movements, the feeling of the room around you is spinning or moving (vertigo), flu-like symptoms such as fever, chills and muscle aches, imbalance of substances in your blood (metabolic acidosis) it can cause confusion, tiredness, shortness of breath and headaches, other vaccines, but they might not give you as much protection as usual, the coronavirus (COVID-19) vaccine - talk to your doctor or pharmacist about the best time to have it in relation to your cancer treatment. It is also important to empty your bladder regularly and to try to pass urine as soon as you feel the need to go. A low DPD level might mean you are more likely to have severe side effects from these drugs. If you have sex during a course of this treatment, you should use barrier protection such as a condom or dental dam. Hopefully the warm weather will also be to my advantage. If you have any of these symptoms, you should stop taking the capecitabine tablets until you have spoken to your doctor. All food and drink at room temp or higher. It is easier to prevent sickness rather than treating it once it has started. Help to Overcome Problems Effectively. They will slow or stop your drip for a while andgive you medicine to help relieve your symptoms. Oxaliplatin Dose Capecitabine Dose >50 Full dose Give 100% 30 to 50 Full dose Give 75% <30 Omit Omit Hepatic Liver function dose Bilirubin > 3 x ULN Oxaliplatin Capecitabine Dose 100% Omit Note that significantly impaired hepatic function might be a sign of disease progression and require cessation or change of treatment. Talk to your doctor before starting treatment if you think you may want to have a baby in the future. Capecitabine and lapatinib were given orally at escalating doses, starting at capecitabine 1500 mg/m(2)/day on days 1-14 and lapatinib 1000 mg daily on days 1-21. Dont breastfeed during this treatment and for 2 weeks after your final treatment. Arms A and B respectively received 8 cycles of adjuvant XELOX (capecitabine 1000 mg/m 2, bid, d1-14, oxaliplatin 130 mg/m 2, d1, q3W) or SOX (TS-1: 40-60 mg bid, d1-14, oxaliplatin: 130 mg/m 2 d1, q3W). I had a touch of each possible side effect, but limited. Cancer and some cancer treatments can increase the risk of a blood clot. You take capecitabine tablets in the morning. There were some days when I was tired and took a nap. Eat less fibre, avoid raw fruits, fruit juice, cereals and vegetables, and drink plentyto replace the fluid lost. Stay as active as you can for as long as you can. Search our clinical trials database for all cancer trials and studies recruiting in the UK, Questions about cancer? 1. If you have breathing difficulties, take long, deep breaths through your nose. ObjectiveTo compare the efficacy of adjuvant chemotherapy with six or eight cycles of S-1 plus oxaliplatin (SOX) or Capecitabine plus oxaliplatin (XELOX) after D2 resection of GC.Design and participantsWe collected 470 cases of patients with TNM stage II and III GC who underwent D2 gastrectomy in the Harbin Medical University Cancer Hospital from January 2007 to December 2017 and received six . 2011 Jun;9(6):492-500. Doctors usually recommend that people with cancer have a flu vaccination and a coronavirus (covid) vaccination. 1000 milligrams (mg) per square meter (m(2)) 2 times a day for the first 14 days of each 21-day cycle for a maximum of 8 cycles. I have read plenty of the bad results from this chemotherapy combination and I am anxious enough already, so I was wondering if people who have not had too hard a time with it would comment on their experiences, and perhaps why they think they did well, and also any advice on things that I might do to get ready for this experience. This is to make sure they work as well as possible for you. This issue has come up here in the past and hopefully others can chime in. Or less commonly you may lose weight. Sometimes a reaction happens a few hours after treatment. Sucking ice chips may sometimes help relieve mouth or throat pain. This is because they can make you unwell. Ra-diologicresponse(RR)rateswere74%afterneoadjuvantchemother- The week I was on chemo was the time when I dropped a bit of weight, was fortunate not nauseous, but not hungry. It is often worse towards the end of treatment and for some weeks after it has finished. We cannot list every side effect for this treatment. You might be breathlessand lookpale due to a drop in red blood cells. But if you are having radiotherapy to the head or neck, do not suck on ice. How often and how severe the side effects are can vary from person to person. You take capecitabine tablets twice a day about 12 hours apart. Just started FOLFOX on April 14/17. Capecitabine is an antimetabolite, belonging to the fluoropyrimidine carbamate class. I am an otherwise healthy and active 58 year old man. You might have treatment through a long plastic tubethat goesinto a large vein in your chest. Repeat every 21 days for 8 cycles for high-risk stage III colon cancer (any T4 and . I had chemo on Monday, took the next 2 days off and then worked for the next 2 weeks with no problem. Capecitabine can affect how the heart works. CAPOX (also called XELOX) - capecitabine and oxaliplatin; capecitabine alone; Stage 4 or recurrent . This is for 2 weeks following their vaccination. Ugh. I need to head out very shortly, and will try to write more later this evening. Talk to your doctor or nurse about effective contraception before starting treatment. Our Cancer Information Nurse Specialists are dedicated cancer nurses available to talk to on our Macmillan Cancer Support Line. You take capecitabine tablets twice a day. I had it surgically removed on March 22. For colorectal cancer: I liked Gold Bond Aloe, but everyone has their favorite. I'm also new here. Kick it to the side and be positve. Results: Ten patients received treatment per study protocol. This can happen whilst you have oxaliplatin or within a few hours of it finishing. I was less tired and able to work more. The arm I get the iv in is sore for a few days after as well, so I always get it in my left arm because I'm right handed. You usually take the tablets twice a day, about 12 hours apart. Doing gentle exercises each day can keep your energy up. If you do have a reaction, it can be treated quickly. Live vaccines contain a very weak version of the illness they are vaccinating you against. Haller DG, Tabernero J, Maroun J, et al. Always tell your doctor, nurse or pharmacist about any side effects you have. Infections can sometimes be life threatening. Patients in both groups received adjuvant chemotherapy (capecitabine or fluorouracil and oxaliplatin) after CRT. avoid alcohol, caffeine, milk products, high-fat foods and high-fibre foods. If you have low levels of an enzyme called DPD (DPD deficiency), you may have a higher risk of severe or life-threatening side effects. Well, I can't tell you what to do, so let me re-word that. The content on this site is for informational purposes only. You may have some side effects that we have not listed here. Tell your treatment teamif you have this. Depending on your needs, you may have between 4 and 8 cycles. If the number of white blood cells is low, you are more likely to get an infection. If you have pain or notice any change in your vision, always tell your doctor or nurse. Feeling tired is a common side effect of this treatment. Cancer drugs can interact with some other medicines and herbal products. Capecitabine, Fluorouracil, and Oxaliplatin. It is also known as colorectal cancer. You may get some of the side effects we mention, but you are unlikely to get all of them. I was good for over a year and now I have two mets in one lung so I'm on Xeloda for that. Put it on hands and feet religiously, morning and night to minimize problems. All three drugs, whether used singly or as part of a combination regimen, are relatively well tolerated and have "milder" adverse effects when compared to other chemotherapy drugs. Are you going to be on Avastin as well? This is called palmar-plantar or hand-foot syndrome. FOLFIRNOX can be used in different ways. First published: March 2013 and regularly updated on the Gov.UK website, Handbook of Cancer Chemotherapy (8th edition) But the team was on the road One of the things that is most important it try not to worry or dwell on this s--t that has been handed to you. Always tell other doctors, nurses, pharmacists or dentists that youre having this treatment. This treatment may cause headaches. Aims: To determine the efficacy of the combination of oxaliplatin and capecitabine in patients with advanced colorectal cancer. You can talk to your cancer doctor about your risk of having DPD deficiency before you start treatment. I was on it in the winter and was often shocked at what would set it off in the house which was warm. You may not be able to become pregnant or father a child after treatment with thesedrugs. Also operating in Northern Ireland. Note that the new diet pill are often known as just one that contains associate innovative active ingredient or a novel combination of various active ingredients. It is important to get any infection treated as soon as possible. I'm not sure if this is related to the Capecitabine or the Oxaliplatin that I get via infusion every 3 weeks. Find out about when you might have it,how you have it and possible side effects. This treatment can reduce the number of white blood cells in your blood. Unfortunately I now have more lung tumours so waiting for an appointment to see what is recommended. Prospective data on prevalence of oxaliplatin induced acute and long-term neuropathy in a real-life patient population and its effects on quality of life (QOL) and survival is limited, and scarce in CAPOX versus . Capecitabine 14/7 (267 or 400 mg/kg) and 7/7 (467 or 700 mg/kg) schedules in doublet and triplet combinations with optimally dosed bevacizumab (5 mg/kg) and oxaliplatin (6.7 mg/kg) were . You can help reduce the risk of developing a blood clot by: You may be given anticoagulants to help prevent a clot. Capecitabine has the potential to replace 5-FU/LV as the optimal combination partner for oxaliplatin at a higher cost. Try to pace yourself and plan your day so you have time to rest. Glad your comfortable with your decision. If you get a high temperature, let your health care teamknow straight away. Brilliant news . It is normal. sometime have programs to help with the cost. You may have symptoms such as: Tell your doctor or nurse if you have these symptoms. They can give you advice and prescribe creams to improve any symptoms you have. I should note that it was over a year before the weirdness diminished in my hands and feet and for some those effects were permanent. Is often worse towards the end of treatment and for 2 weeks with no problem so i on. ) vaccination can interact with some other medicines and herbal products or throat.! 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